Inhibition shapes the organization of hippocampal representations. Issue 9 (29th September 2017)

• Record Type: Journal Article
• Authors: McKenzie, Sam
• Other Names: Eichenbaum Dr. Howard guestEditor.
• Is Part Of: Hippocampus. Volume 28:Issue 9(2018)
• Page Start: 659
• Page End: 671
• Publication Date: 2017-09-29
• Subjects: feedback inhibition -- feedforward inhibition -- memory schema -- remapping -- shunting inhibition; Hippocampus (Brain) -- Periodicals; 612.825
• DOI: 10.1002/hipo.22803
• Languages: English
• ISSNs: 1050-9631

Abstract

Abstract: Hippocampal neurons become tuned to stimuli that predict behaviorally salient outcomes. This plasticity suggests that memory formation depends upon shifts in how different anatomical inputs can drive hippocampal activity. Here, I present evidence that inhibitory neurons can provide such a mechanism for learning‐related changes in the tuning of pyramidal cells. Inhibitory currents arriving on the dendrites of pyramidal cells determine whether an excitatory input can drive action potential output. Specificity and plasticity of this dendritic modulation allows for precise, modifiable changes in how afferent inputs are integrated, a process that defines a neuron's receptive field. In addition, feedback inhibition plays a fundamental role in biasing which excitatory neurons may be co‐active. By defining the rules of synchrony and the rules of input integration, interneurons likely play an important role in the organization of memory representation within the hippocampus.