Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non‐diabetic subjects with periodontitis: A cohort study. (21st October 2018)

• Record Type: Journal Article
• Authors: Duarte, Poliana Mendes; Feres, Magda; Yassine, Lina Lameh Smeili; Soares, Geisla Mary Silva; Miranda, Tamires Szeremeske; Faveri, Marcelo; Retamal‐Valdes, Belen; Figueiredo, Luciene Cristina
• Is Part Of: Journal of clinical periodontology. Volume 45:Number 11(2018)
• Page Start: 1326
• Page End: 1335
• Publication Date: 2018-10-21
• Subjects: amoxicillin -- chronic periodontitis -- dental scaling -- diabetes mellitus -- metronidazole -- root planing; Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12994
• Languages: English
• ISSNs: 0303-6979

Abstract

Abstract: Aim: To evaluate if non‐diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX). Material and Methods: Diabetic and nondiabetic subjects with severe periodontitis received SRP + MTZ (400 mg/thrice a day [TID]) + AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by checkerboard DNA–DNA hybridization for 40 bacterial species. Subjects were monitored at baseline, 3, 6 and 12 months post‐therapy. Results: Twenty‐nine type 2 diabetics and 29 non‐diabetic subjects participated of this study. Of the non‐diabetics and diabetics, 68.9% and 75.9%, respectively, reached the clinical endpoint for treatment (≤4 sites with probing depth [PD] ≥5 mm) at 1 year post‐therapy ( p > 0.05). The diabetic group presented lower mean clinical attachment gain from baseline to 1 year post‐therapy and higher mean proportions of the red and orange complexes than the non‐diabetic group ( p < 0.05). Conclusions: Non‐diabetic subjects with severe periodontitis did not respond better than type 2 diabetic subjects to the treatment protocol of SRP + MTZ + AMX, both in terms of achieving the clinical endpoint for treatment and of PD improvement. Diabetic subjects exhibited a slightly worse microbiological response and showed a healing process more associated with gingival recession than the non‐diabetics.