Association between urinary sodium excretion and coronary heart disease in hospitalized elderly patients in China. Issue 8 (August 2018)

• Record Type: Journal Article
• Authors: Li, Chun-lin; Wang, Hai-jun; Si, Quan-jin; Zhou, Jin; Li, Kai-liang; Ding, Yu
• Is Part Of: Journal of international medical research. Volume 46:Issue 8(2018)
• Page Start: 3078
• Page End: 3085
• Publication Date: 2018-08
• Subjects: Aged -- coronary heart disease -- sodium -- dietary -- sodium/potassium ratio -- sodium excretion; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060518772222
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: This study was performed to evaluate the association between urinary sodium excretion and coronary heart disease (CHD) in hospitalized elderly patients in China. Methods: The 24-h urinary excretion specimens of 541 patients were collected, and the serum creatinine concentration and urinary sodium/potassium ratio were measured. Associations were explored by multivariate logistic regression analysis. Results: The mean 24-h urinary sodium excretion was 200.4 mmol, corresponding to 11.7 g of salt intake. Both of these values were higher in men than in women. The salt intake of 80- to 89-year-old patients was significantly lower than that of 70- to 79-year-old patients. The 24-h urinary sodium excretion and spot urine Na/K ratios were significantly higher in overweight/obese and hypertensive patients. The 24-h urinary sodium excretion of men who smoked was significantly higher than that of women. The spot urine Na/K ratio was significantly higher in patients with cerebral thrombosis. The urinary Na/K ratio, smoking status, and hypertension were independent risk factors for CHD. Conclusions: This cross-sectional survey suggests that the Na/K ratio may better represent salt loading than Na excretion alone in studying the association between sodium intake and CHD. There was no association between sodium and CHD prevalence.