Endometrial Stromal Sarcoma With Hyalinizing Giant Rosettes, Mimicking Low-Grade Fibromyxoid Sarcoma. (September 2018)

• Record Type: Journal Article
• Authors: Kolson Kokohaare, Eva; Strauss, Dirk C.; Jones, Robin L.; Thway, Khin
• Is Part Of: International journal of surgical pathology. Volume 26:Number 6(2018)
• Page Start: 525
• Page End: 527
• Publication Date: 2018-09
• Subjects: endometrial stromal sarcoma -- collagenous rosettes -- JAZF1-SUZ12 -- hyalinizing spindle cell tumor with giant rosettes -- low-grade fibromyxoid sarcoma -- mimic -- sarcoma; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896918767547
• Languages: English
• ISSNs: 1066-8969

Abstract

We highlight a rare variant pattern of low-grade endometrial stromal sarcoma showing extensive collagenous rosette formation, closely mimicking low-grade fibromyxoid sarcoma. Additionally, this neoplasm showed diffuse and strong expression of muscle markers, favoring an initial diagnosis of leiomyosarcoma. Reverse transcription-polymerase chain reaction showed the presence of JAZF1-SUZ12 fusion transcripts, and this highlights the broad morphologic and immunophenotypic spectrum of endometrial stromal sarcoma.