Postradiation Synovial Sarcoma of the Common Bile Duct: A Previously Unreported Anatomic Site. (August 2018)

• Record Type: Journal Article
• Authors: Herrera-Goepfert, Roberto
• Is Part Of: International journal of surgical pathology. Volume 26:Number 5(2018)
• Page Start: 469
• Page End: 474
• Publication Date: 2018-08
• Subjects: synovial sarcoma -- radiotherapy -- translocation -- SS18 -- SSX -- extrahepatic biliary tree; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896917752863
• Languages: English
• ISSNs: 1066-8969

Abstract

Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11.2) translocation yields unique SS18-SSX fusion genes. Synovial sarcoma has been related to radiotherapy, but no synovial sarcoma has been associated with the digestive system. This article describes the case of a synovial sarcoma arising along the extrahepatic biliary tree, 10 years after the application of an abdominal radiotherapy schedule due to a retroperitoneal metastatic seminoma in a male who developed progressive obstructive jaundice. Ninety percent of the analyzed cells carried the SS18 gene with separation of sequences, thus denoting a translocation. There are only 8 post-radiotherapy synovial sarcomas that have been reported previously, and this is the first report of a radiotherapy-related synovial sarcoma arising from the extrahepatic biliary tree, and the second case described in this anatomic region.