Computer simulation analysis of source‐detector position for percutaneously measured O2‐gas signal in a three‐dimensional preterm infant lung. Issue 11 (31st July 2018)

• Record Type: Journal Article
• Authors: Liao, Peilang; Larsson, Jim; Krite Svanberg, Emilie; Lundin, Patrik; Swartling, Johannes; Lewander Xu, Märta; Bood, Joakim; Andersson‐Engels, Stefan
• Is Part Of: Journal of biophotonics. Volume 11:Issue 11(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-31
• Subjects: computational phantom -- light transport simulation -- preterm infants -- respiratory distress syndrome -- tunable diode laser absorption spectroscopy; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201800023
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : Further improvements in the clinical care of our most vulnerable patients—preterm infants—are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will become a valuable clinical diagnostic tool for monitoring the lung function of these patients. Today, the technology is, for this application, in an early stage and further investigations are needed. In the present study, a three‐dimensional computer model of the thorax of an infant is constructed, from a set of CT images. Light transport simulations are performed to provide information about the position dependence of the laser‐ and detector probe on the thorax of the infant. The result of the simulations, based on the study method and the specified model used in this work, indicates that measurement geometries in front and on the side of the lung are favorable in order to obtain a good gas absorption signal. Abstract : Light transport simulation was performed on a three‐dimensional model constructed from CT images of a 1.7 kg premature infant to obtain percutaneously measured O2 ‐gas signal in the lungs for different measurement geometries. This work will improve the understanding of dependence of measured gas signal on the source‐detector positions.