Phthaloyl Dichloride–DMF Mediated Synthesis of Benzothiazole‐based 4‐Formylpyrazole Derivatives: Studies on Their Antimicrobial and Antioxidant Activities. (17th September 2018)

• Record Type: Journal Article
• Authors: Bala, Renu; Kumari, Poonam; Sood, Sumit; Kumar, Vinod; Singh, Nasib; Singh, Karan
• Is Part Of: Journal of heterocyclic chemistry. Volume 55:Number 11(2018)
• Page Start: 2507
• Page End: 2515
• Publication Date: 2018-09-17
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3282
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : Benzothiazole‐based pyrazole derivatives prepared by a molecular hybridization approach with an aim to influence the biological activity significantly. Efficient conversion of hydrazones3a–k derived from their corresponding methyl ketones to 4‐formylpyrazoles4a–k was carried out at 60°C in dioxane, using the Vilsmeier–Haack reagent isolated from phthaloyl dichloride and N, N ‐dimethylformamide. The newly synthesized compounds4a–k and hydrazones3a–k were screened in vitro for their antimicrobial activities using the broth macrodilution method. The compounds4a–k were also screened for their antioxidant activities using the DPPH radical scavenging assay. Some of the synthesized compounds showed significant antibacterial and antifungal activities as evident from their minimum inhibitory concentrations. Compound4d showed remarkable antioxidant activity. Abstract :