Meta-analysis update of association between dopamine transporter SLC6A3 gene polymorphism and smoking cessation. (August 2018)

• Record Type: Journal Article
• Authors: Choi, Hye Duck; Shin, Wan Gyoon
• Is Part Of: Journal of health psychology. Volume 23:Number 9(2018)
• Page Start: 1250
• Page End: 1257
• Publication Date: 2018-08
• Subjects: genetic testing -- health psychology -- nicotine dependence -- smoker -- smoking cessation; Clinical health psychology -- Periodicals; 613.019
• DOI: 10.1177/1359105316648479
• Languages: English
• ISSNs: 1359-1053

Abstract

The SLC6A3 gene is involved in the dopamine pathway, which influences smoking behavior. This study was conducted to present updated results of a meta-analysis to evaluate the association between SLC6A3 polymorphism and smoking cessation. In total, eight studies were assessed, and 9-repeat alleles and no 9-repeat alleles were compared by smoking cessation outcomes. No significant association between SLC6A3 genotype and smoking cessation was observed for the main analysis (odds ratio = 1.128; 95% confidence interval = 0.981–1.298). In conclusion, the genetic variations in SLC6A3 are not associated with smoking cessation, which is not consistent with the results of the previous meta-analysis.