Treatment and skin decontamination of sarin intoxicated mice. Issue 3 (16th March 2018)

• Record Type: Journal Article
• Authors: Vučemilović, Ante; Hadžija, Mirko; Žuntar, Irena
• Is Part Of: Toxicological and environmental chemistry. Volume 100:Issue 3(2018)
• Page Start: 361
• Page End: 371
• Publication Date: 2018-03-16
• Subjects: Treatment -- mice -- mineral cationic carrier (MCC) -- sarin -- skin decontamination; Toxicology -- Periodicals; Environmental chemistry -- Periodicals; 571.95
• DOI: 10.1080/02772248.2018.1523413
• Languages: English
• ISSNs: 0277-2248

Abstract

Abstract: This study aimed at evaluating the efficacy of oral treatment and skin decontamination with the mineral cationic carrier in sarin-intoxicated mice. Mice were contaminated with increasing percutaneous sarin doses and decontaminated. Furthermore, the surviving mice were treated per os . The behavioral patterns of the surviving animals were monitored for 72 h, including the animals' posture, desire for food and water, and approach and touch response. The results showed the mineral cationic carrier to be capable of efficiently decontaminating animals percutaneous poisoned with triple lethal dose. The comparison of behavioral pattern of control animals against those treated per os showed statistically significant differences. Oral treatment with mineral cationic carrier may be a detoxification tool against nerve agents' poisoning, and this merits further research.