Biosynthesis of 7, 8-dihydroxyflavone glycosides via OcUGT1-catalyzed glycosylation and transglycosylation. Issue 7 (3rd July 2018)

• Record Type: Journal Article
• Authors: Yuan, Shuai; Yang, Yan; Kong, Jian-Qiang
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 7(2018)
• Page Start: 662
• Page End: 674
• Publication Date: 2018-07-03
• Subjects: Glycosyltransferase -- OcUGT1 -- 7, 8-dihydroxyflavone -- glycodiversification -- glycosylation -- trans-glycosylation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1481053
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Herein, a flavonoid glycosyltransferase (GT) OcUGT1 was determined to be able to attack C-8 position of 7, 8-dihydroxyflavone (7, 8-DHF) via both glycosylation and transglycosylation reactions. OcUGT1-catalyzed glycosylation of 7, 8-DHF resulted in the formation of two monoglycosides 7- O -β-D-glucosyl-8-hydroxyflavone (1a ), 7-hydroxy-8- O -β-D-glucosylflavone (1b ), as well as one diglycoside 7, 8-di- O -β-D-glucosylflavone (1c ). Under the action of OcUGT1, inter-molecular trans-glycosylations from aryl β-glycosides to 7, 8-DHF to form monoglycosides1a and1b were observable. Abstract :