A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder. Issue 4 (4th July 2018)

• Record Type: Journal Article
• Authors: Hellmuth, Joanna; Milanini, Benedetta; Masliah, Eliezer; Tartaglia, Maria Carmela; Dunlop, Miranda B.; Moore, David J.; Javandel, Shireen; DeVaughn, Saskia; Valcour, Victor
• Is Part Of: Neurocase. Volume 24:Issue 4(2018)
• Page Start: 213
• Page End: 219
• Publication Date: 2018-07-04
• Subjects: HIV-associated neurocognitive disorder -- Alzheimer's disease -- neuropathology -- dementia -- neuropsychological testing; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2018.1530362
• Languages: English
• ISSNs: 1355-4794

Abstract

ABSTRACT: We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.