Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation. (November 2018)

• Record Type: Journal Article
• Authors: Nevalainen, Jaana; Ignatius, Jaakko; Savolainen, E.-R.; Ryynanen, Markku; Jarvenpaa, Jouko
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 230(2018)
• Page Start: 32
• Page End: 35
• Publication Date: 2018-11
• Subjects: Preeclampsia -- Pregnancy complication -- Thrombophilia; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2018.09.016
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: Maternal thrombophilia is a risk factor for adverse pregnancy outcomes. The aim of this study was to elucidate the controversial role of fetal and paternal thrombophilia in the development of severe placenta-mediated pregnancy complications. Study Design: The study group comprised 126 mothers, 72 fetuses and 58 fathers. 111 mothers, 50 fetuses and 91 fathers acted as controls. 106 couples were selected to study the thrombophilias of paternal inheritance, 58 from the study group and 48 from the control group. The prevalence of factor V Leiden mutation, prothrombin G20210 A mutation and homozygous 10-methylenetetrahydrofolate reductase C677 T mutations were compared between the study and control groups to study whether maternal, fetal or paternal thrombophilias increase the risk of severe preeclampsia, intrauterine growth restriction, placental abruption and stillbirth. Results: The total prevalence of fetal thrombophilic mutations was 8.3% in the study group and 14.0% in the control group. Paternal prevalence of thrombophilic mutations was 6.8% and 4.3%, respectively. There were no statistical differences between fetal or paternal thrombophilic mutations between the study and control groups. Conclusion: Fetal or paternal factor V Leiden mutation is not associated with severe placenta-mediated pregnancy complications.