Photothermally tunable biodegradation of implantable triboelectric nanogenerators for tissue repairing. (December 2018)

• Record Type: Journal Article
• Authors: Li, Zhe; Feng, Hongqing; Zheng, Qiang; Li, Hu; Zhao, Chaochao; Ouyang, Han; Noreen, Sehrish; Yu, Min; Su, Fan; Liu, Ruping; Li, Linlin; Wang, Zhong Lin; Li, Zhou
• Is Part Of: Nano energy. Volume 54(2018)
• Page Start: 390
• Page End: 399
• Publication Date: 2018-12
• Subjects: Implantable nanogenerator -- Tunable biodegradation -- Au nanorods -- Near-infrared -- Photothermal; Nanoscience -- Periodicals; Nanotechnology -- Periodicals; Nanostructured materials -- Periodicals; Power resources -- Technological innovations -- Periodicals; Nanoscience; Nanostructured materials; Nanotechnology; Power resources -- Technological innovations; Periodicals; 621.042
• DOI: 10.1016/j.nanoen.2018.10.020
• Languages: English
• ISSNs: 2211-2855

Abstract

Abstract: Implantable triboelectric nanogenerators (iTENGs) are promising to work as sustainable power source for implanted healthcare electronic devices. In this study, we fabricated a serial of biodegradable (BD) iTENGs and effectively tuned their degradation process in vivo by employing Au nanorods (AuNRs), which responded to the near-infrared (NIR) light sensitively. The implanted BD-iTENG worked well for more than 28 days in vivo, without NIR treatment. When NIR treatment was applied, the output of AuNRs-BD-iTENG rapidly reduced to 0 within 24 h and the device was mostly degraded in 14 days. This showed that the in vivo degradation of our BD-iTENG could be triggered and come into effect very quickly with rational manipulation. The peak value of in vitro and in vivo output voltage generated by the AuNRs-BD-iTENG were 28 V and 2 V, respectively. Moreover, the in vivo output voltage was applied on fibroblast cells and demonstrated a significant acceleration for cell migration across the scratch, which was very beneficial to wound healing process. In addition, we discovered that the alternating BD-iTENG output was as efficient as direct current (DC) stimuli. The mechanisms were investigated. Our work has demonstrated the feasibility of building a photothermally tunable BD-iTENG as a transient power source for biomedical healthcare electronics. Graphical abstract: We fabricate a serial of biodegradable (BD) implantable triboelectric nanogenerators (iTENGs) and successfully tuned their degradation process in vivo by near-infrared (NIR) photothermal manipulation. The degradation can be triggered and come into effect within 12 h after NIR treatment. The output of the BD-iTENG can significantly accelerate fibroblast migration across the scratch and thus enhance tissue repair process. Highlights: We fabricated a serial of biodegradable (BD) iTENG whose in vivo degradation process can be rationally manipulated by the near-infrared (NIR) light. The output of our BD-iTENG significantly accelerated the fibroblast cells migration across the scratch, suggesting a promising application for wound healing.