The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress. (February 2019)

• Record Type: Journal Article
• Authors: Liu, Min; Jia, Shenglan; Dong, Ting; Han, Yuan; Xue, Jingchuan; Wanjaya, Elvy Riani; Fang, Mingliang
• Is Part Of: Chemosphere. Volume 216(2019)
• Page Start: 472
• Page End: 478
• Publication Date: 2019-02
• Subjects: Bisphenol A diglycidyl ether -- Bisphenol plasticizers -- Dust -- Urine -- and oxidative stress; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2018.10.090
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Bisphenol A diglycidy ether (BADGE) and its derivatives are epoxy resins and widely used as emerging plasticizers in food packages and material coating. Though known as endocrine disruptors, little information is available on their occurrence, exposure routes and toxicity. Besides, the analysis of BADGE and its derivatives has always been a challenge due to their reactive chemical properties and the background contamination. Therefore, we firstly developed a novel water-free method to analyze BADGE and its derivatives in dust samples together with other two typical plasticizers bisphenol A (BPA) and bisphenol S (BPS). In order to investigate the levels in paired dust and urine samples, 33 paired samples were collected from Singapore. In both dust and urine samples, the predominant compounds were BPA, BADGE-2H2 O and BPS. A significantly positive correlation of BPA levels in paired dust and urine samples was observed in this small-scale study. To tentatively explore the human health effect from exposure to these bisphenol plasticizers, we assessed the correlation between the urinary concentrations of these compounds and oxo-2'-deoxyguanosine (8-OHdG), an oxidative stress biomarker. The result showed that 8-OHdG levels in urine samples was positively correlated with urinary BPA level and body mass index (BMI), suggesting that elevated oxidative stress might be associated with BPA exposure and obesity. In the future, a larger scale study is warranted due to the limited sample size in this study. Graphical abstract: Highlights: Development of a novel water-free method to analyse BADGE in the dust. BADGE and its derivatives were widely detected in the dust and urine samples. BPA in the urine was significantly correlated with BPA in the dust. BPA in the urine was significantly correlated with oxidative stress biomarker.