First whole genome sequencing of Russian isolate of Capnocytophaga canimorsus, opportunistic pathogen causing lethal sepsis. (December 2018)

• Record Type: Journal Article
• Authors: Shelenkov, Andrey A.; Karan, Lyudmila S.; Mihaylova, Yulia V.; Yanushevich, Yuri G.; Shipulin, German A.; Shagin, Dmitriy A.
• Is Part Of: Microbial pathogenesis. Volume 125(2018)
• Page Start: 493
• Page End: 496
• Publication Date: 2018-12
• Subjects: Capnocytophaga canimorsus -- Whole genome sequencing -- Sepsis; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2018.10.020
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. However, when it is transmitted to human subjects via animal bites or scratches, it can cause severe complications like endocarditis or even lethal septic shock, especially in immunocompromised persons. In this study, we performed the first whole-genome sequencing on Illumina HiSeq platform of Russian isolate of C. canimorsus that have caused lethal sepsis in 51-old male from Moscow. We believe that the availability of genomic sequence and annotation for the given strain could be useful for future epidemiological surveillance studies in Russia and other countries. Highlights: Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. It can cause septic shock when transmitted to human subjects via animal bites. Only 4 whole genomes of C. canimorsus are currently available. We performed the first whole-genome sequencing of Russian isolate of C. canimorsus . Genomic annotation obtained is useful for future epidemiological surveillance.