Evaluation of the oxidative stress–related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population. (July 2018)

• Record Type: Journal Article
• Authors: Liu, Ding; Liu, Lei; Hu, Zhongyang; Song, Zhi; Wang, Yaqin; Chen, Zhiheng
• Is Part Of: Diabetes & vascular disease research. Volume 15:Number 4(2018:Jul.)
• Page Start: 336
• Page End: 339
• Publication Date: 2018-07
• Subjects: Type 2 diabetes mellitus -- carotid plaque -- oxidative stress -- ALOX5 gene -- ALOX5AP gene -- GPX1 gene -- GPX3 gene -- MPO gene -- genetic risk factor; Diabetic angiopathies -- Periodicals; 616.462005
• DOI: 10.1177/1479164118755044
• Languages: English
• ISSNs: 1479-1641

Abstract

Aim: Type 2 diabetes mellitus is a polygenic metabolic disorder resulting from oxidative stress, the root cause of insulin resistance, β-cell dysfunction and impaired glucose tolerance. The aim of this study was to investigate the role of oxidative stress–related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO in type 2 diabetes mellitus susceptibility in the Chinese Han population. Methods: A total of 396 type 2 diabetes mellitus patients and 678 controls were recruited. The ALOX5 rs10900213, ALOX5AP rs4293222, GPX1 rs1050450, GPX3 rs3828599 and MPO rs2107545 gene polymorphisms were genotyped. Results: We found one single-nucleotide polymorphism in the MPO gene was associated with type 2 diabetes mellitus susceptibility [rs2107545: odds ratio = 1.563 (1.166–2.096); p = 0.003], after adjusting for covariates. Furthermore, we also considered the likely complexity of effects of genetic and conventional risk factors in type 2 diabetes mellitus–related vascular complications, such as carotid plaques. Our analysis revealed that the GPX1 rs1050450 and MPO rs2107545 were significantly associated with increased risk of carotid plaques in type 2 diabetes mellitus patients. Conclusion: Our study presents novel evidence for main effects of MPO gene on type 2 diabetes mellitus susceptibility. Furthermore, our study supported the association between variants of oxidative stress–related genes ( GPX1 and MPO ) and carotid plaques in type 2 diabetes mellitus patients, which indicated a modulation of type 2 diabetes mellitus–related vascular complication susceptibility by genetic predisposition.