Maximum-likelihood joint image reconstruction and motion estimation with misaligned attenuation in TOF-PET/CT. (20th January 2016)

• Record Type: Journal Article
• Authors: Bousse, Alexandre; Bertolli, Ottavia; Atkinson, David; Arridge, Simon; Ourselin, Sébastien; Hutton, Brian F; Thielemans, Kris
• Is Part Of: Physics in medicine & biology. Volume 61:Number 3(2016:Feb.)
• Page Start: L11
• Page End: L19
• Publication Date: 2016-01-20
• Subjects: attenuation correction -- time-of-flight PET -- motion estimation -- attenuation mismatch -- maximum-likelihood; Biophysics -- Periodicals; Medical physics -- Periodicals; 610.153
• DOI: 10.1088/0031-9155/61/3/L11
• Languages: English
• ISSNs: 0031-9155

Abstract

Abstract: This work is an extension of our recent work on joint activity reconstruction/motion estimation (JRM) from positron emission tomography (PET) data. We performed JRM by maximization of the penalized log-likelihood in which the probabilistic model assumes that the same motion field affects both the activity distribution and the attenuation map. Our previous results showed that JRM can successfully reconstruct the activity distribution when the attenuation map is misaligned with the PET data, but converges slowly due to the significant cross-talk in the likelihood. In this paper, we utilize time-of-flight PET for JRM and demonstrate that the convergence speed is significantly improved compared to JRM with conventional PET data.