Synthesis and characterization of hybrid Anderson hexamolybdoaluminates(III) functionalized with indometacin or cinnamic acid. Issue 11 (24th October 2018)

• Record Type: Journal Article
• Authors: Gumerova, Nadiia I.; Blazevic, Amir; Caldera Fraile, Tania; Roller, Alexander; Giester, Gerald; Rompel, Annette
• Is Part Of: Acta crystallographica. Volume 74:Issue 11(2018)
• Page Start: 1378
• Page End: 1383
• Publication Date: 2018-10-24
• Subjects: polyoxomolybdate -- organic–inorganic hybrids -- alkoxylation -- post‐functionalization -- hexamolybdoaluminate -- crystal structure -- indometacin -- cinnamic acid -- antibacterial activity; Crystallography -- Periodicals; Crystals -- Periodicals; 548.3
• DOI: 10.1107/S2053229618012536
• Languages: English
• ISSNs: 2053-2296

Abstract

Abstract : A post‐functionalization protocol was used for the synthesis of two new tris‐hybrid Al‐centred Anderson‐type polyoxomolybdates with indometacin or cinnamic acid. Abstract : The single‐side Al‐centred tris‐functionalized hybrid organic–inorganic Anderson polyoxomolybdates (C16 H36 N)3 [Al(OH)3 Mo6 O18 (OCH2 )3 CNH(C10 H8 O)]·C9 H7 N·4CH3 OH·5H2 O (AlMo6 ‐NH‐Cin ; Cin is cinnamic acid, C10 H9 O2 ) and (C16 H36 N)3 [Al(OH)3 Mo6 O18 (OCH2 )3 CNH(C19 H15 ClNO3 )]·9H2 O (AlMo6 ‐NH‐Indo ; Indo is indometacin, C19 H16 ClNO4 ) have been prepared in a mild three‐step synthesis and structurally characterized by single‐crystal X‐ray diffraction, 1 H NMR and IR spectroscopies and elemental analysis. BothAlMo6 ‐NH‐Cin andAlMo6 ‐NH‐Indo crystallize in the orthorhombic space group Pbca . The antibacterial activities ofAlMo6 ‐NH‐Cin andAlMo6 ‐NH‐Indo against the Gram‐negative human mucosal pathogen Moraxella catarrhalis were investigated by determination of the minimum inhibitory concentration, which is 32 µg ml −1 forAlMo6 ‐NH‐Cin and 256 µg ml −1 forAlMo6 ‐NH‐Indo .