Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology. (19th September 2018)

• Record Type: Journal Article
• Authors: Tacke, Moritz; Rupp, Nina; Gerstl, Lucia; Heinen, Florian; Vill, Katharina; Bonfert, Michaela; Neubauer, Bernd Axel; Bast, Thomas; Borggraefe, Ingo
• Other Names: Baumeister F A M investigator.; Baethmann M investigator.; Schreiber‐Gollwitzer B investigator.; Bentele K investigator.; Blank C investigator.; Held J investigator.; Blank H M investigator.; Liebrich K investigator.; Bode H investigator.; Braun J investigator.; Bosch F investigator.; Wagner R investigator.; Brandl U investigator.; Wetzel K investigator.; Brockmann K investigator.; Schlockwerder C investigator.; Dahlem P investigator.; Baudler I investigator.; Ernst J P investigator.; Mayer H investigator.; Feldmann E investigator.; Pattber‐Wolff A investigator.; Fiedler A investigator.; Sonnleitner S investigator.; Gerigk M investigator.; Heß S investigator.; Feiereis T investigator.; Hikel C investigator.; Hoffmann H G investigator.; Rickeshenrich A investigator.; Kieslich M investigator.; Dewitz R investigator.; Baz Bartels M investigator.; Klepper J investigator.; Kleuker S investigator.; Kluger G investigator.; Kirsch A investigator.; Koch H investigator.; Meerpohl U investigator.; Koch W investigator.; Korinthenberg R investigator.; Stehle‐Renner B investigator.; Krois I investigator.; Wegener A investigator.; Kühne H investigator.; Weiß C investigator.; Kurlemann G investigator.; Elkemann U investigator.; Mandl M investigator.; Friedl A investigator.; Mause U investigator.; Müller M investigator.; Navratil P investigator.; Iken U investigator.; Opp J investigator.; Walter J investigator.; Penzien J investigator.; Prietsch V investigator.; Siegrist B investigator.; Quattländer A investigator.; Rating D investigator.; Reuner G investigator.; Schara U investigator.; Shamdeen M G investigator.; Struchholz H investigator.; prinz A investigator.; Wendker‐Magrabi H investigator.; Stephani U investigator.; Muhle H investigator.; Carlsson G investigator.; Straßburg H M investigator.; Ottensmeier H investigator.; Töpke B investigator.; Tatsek K investigator.; Trollmann R investigator.; Poida‐Herzing E investigator.; Tuschen‐Hofstätter E investigator.; Menschig M investigator.; Waltz S investigator.; Pickartz A investigator.; Weber G investigator.; Gehnen T investigator.; Wien F U investigator.; Antemann J investigator.; Wolff M investigator.; Serra E investigator.; Polster T investigator.; Freitag H investigator.; Sönmez Ö investigator.; Rheinhardt K investigator.; Traus M investigator.; chröder A investigator.; Hoovey S investigator.; Navratil C investigator.;
• Is Part Of: Acta neurologica Scandinavica. Volume 138:Number 6(2018)
• Page Start: 475
• Page End: 481
• Publication Date: 2018-09-19
• Subjects: behavior -- cognition -- EEG -- idiopathic epilepsy -- pediatric epilepsy; Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.13015
• Languages: English
• ISSNs: 0001-6314

Abstract

Abstract : Objectives: Neuropsychological sequelae are a feature of benign epilepsy with centrotemporal spikes (BECTS) in children. A correlation between the frequency of interictal EEG discharges and the cognitive as well as behavioral profile of the patients has been suspected but not proven. Materials and methods: Children with BECTS that had not yet been treated were included into a randomized controlled trial. In the initial visit, EEGs were recorded. The frequency of interictal discharges was quantified. Correlations between the discharge frequency and the performance in a neuropsychological test battery were examined. Results: The cognitive test results were within or slightly above normal range (Culture‐free intelligence test: 99.4%‐confidence interval [CI]: [50.3, 59.9], test standardized to a population mean of 50). Parent‐reported behavioral abnormalities were statistically significantly increased (CBCL total score CI: [51.9, 61.9], population mean as above). Correlations between the frequency of interictal epileptic discharges and the test results could not be identified (lowest encountered P ‐value: 0.034, not significant after correction for multiple testing). Conclusion: The data do not support the hypothesis that the frequency of the interictal EEG discharges influences the neurocognitive performance or behavioral parameters of children with BECTS.