The effect of statins on the recurrence rate of atrial fibrillation after catheter ablation: A meta‐analysis. Issue 11 (4th October 2018)

• Record Type: Journal Article
• Authors: Peng, Hong; Yang, Yuan; Zhao, Yue; Xiao, Hua
• Is Part Of: Pacing and clinical electrophysiology. Volume 41:Issue 11(2018)
• Page Start: 1420
• Page End: 1427
• Publication Date: 2018-10-04
• Subjects: atrial fibrillation -- catheter ablation -- statins; Cardiac pacing -- Periodicals; Electrophysiology -- Periodicals; 617.4120645
• DOI: 10.1111/pace.13485
• Languages: English
• ISSNs: 0147-8389

Abstract

Abstract: Background: To more precisely evaluate the effect of statins on patients with atrial fibrillation (AF) after catheter ablation, we performed a meta‐analysis of published studies. Methods: We searched PubMed, EMBASE, and Cochrane Library for all relevant published articles from the date of inception to April 2017. Odds ratios (OR) and 95% confidence intervals (CIs) were then calculated and pooled using a random‐effects model. Statistical heterogeneity was evaluated using the I 2 statistic. Results: Nine studies with a total of 1, 607 patients were included in the analysis. Overall, statins did not reduce the recurrence rate of AF after catheter ablation (OR 0.81, 95% CI 0.59–1.10, P = 0.18). However, in the subgroup analysis, the randomized control trial (RCT) group significantly reduced the recurrence of AF (OR 0.47, 95% CI 0.30–0.75, P = 0.001). Conversely, the retrospective cohort study subgroup also had a negative result (OR 1.03, 95% CI 0.78–1.36, P = 0.82). Conclusions: Statin use was associated with a significantly lower AF recurrence rate in RCTs but not in the whole analysis and the observational studies.