Aptamer‐Decorated DNAsome for Targeted Cancer Therapy. Issue 11 (3rd September 2018)

• Record Type: Journal Article
• Authors: Golla, Murali; Thaddi, Sai Praveen; Perumal, Devanathan; Atchimnaidu, Siriki; Varghese, Reji
• Is Part Of: ChemNanoMat. Volume 4:Issue 11(2018)
• Page Start: 1153
• Page End: 1159
• Publication Date: 2018-09-03
• Subjects: amphiphile -- vesicle -- self-assembly -- cancer -- drug delivery; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201800297
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: Drug delivery using a nanocarrier is one promising approach for cancer therapy. However, the design of nanocarriers that allow the targeted delivery of drugs at the desired location upon demand remains a foremost challenge in cancer therapy. Herein, the design of a DNA based vesicle (DNAsome) as a nanocarrier from the self‐assembly of a DNA amphiphile is reported. The salient features of DNAsome include excellent biocompatibility, high drug encapsulation ability and DNA‐based surface addressability. The surface decoration of the DNAsome with highly information‐rich ssDNA is explored for the integration of cancer cell targeting aptamer through sequence specific DNA hybridization. Selective delivery of anticancer drug into a cancerous cell line is demonstrated using the aptamer decorated DNAsome in an efficient manner. Our results unequivocally show the potential of DNAsome for targeted cancer therapy, and hence could be a promising candidate as a nanocarrier for drug delivery applications. Abstract : Design of a DNAsome from the self‐assembly of a DNA amphiphile is reported. The DNA‐based surface addressability of the DNAsome is explored for the decoration of the surface of DNAsome with a cancer cell targeting aptamer through DNA hybridization; the selective delivery of anticancer drug is also demonstrated.