Circulating biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy assessed by cardiac magnetic resonance. (3rd October 2018)

• Record Type: Journal Article
• Authors: Gawor, Monika; Śpiewak, Mateusz; Kubik, Agata; Wróbel, Aleksandra; Lutyńska, Anna; Marczak, Magdalena; Grzybowski, Jacek
• Is Part Of: Biomarkers. Volume 23:Number 7(2018)
• Page Start: 676
• Page End: 682
• Publication Date: 2018-10-03
• Subjects: Hypertrophic cardiomyopathy -- myocardial fibrosis -- sST2 -- galectin-3 -- GDF-15; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2018.1474261
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Background: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. Objective: The aim of this study was to evaluate usefulness of various biomarkers of myocardial fibrosis and hypertrophy in HCM. Methods: Levels of biomarkers: soluble ST2 (sST2), galectin-3 (Gal-3), growth differentiation factor-15 (GDF-15), NT-proBNP and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis. Results: We observed positive correlations among sST2 levels and left ventricular mass (LVM) ( r = 0.32, p = 0.012), LV mass indexed for the body surface area (LVMI) ( r = 0.27, p = 0.036) and maximal wall thickness (MWT) ( r = 0.31, p = 0.015). No correlation was found between Gal-3 and GDF-15 levels and hypertrophy and fibrosis parameters. We observed positive correlations among hs-cTnT levels and LVM ( r = 0.58, p < 0.0001), LVMI ( r = 0.48, p = 0.0001), MWT ( r = 0.31, p = 0.015) and late gadolinium enhancement (LGE) mass ( r = 0.37, p = 0.003). There were positive correlations between NT-proBNP levels and LVM ( r = 0.33, p = 0.01), LVMI ( r = 0.41, p = 0.001), MWT ( r = 0.42, p < 0.001) and LGE mass ( r = 0.44, p < 0.001). Conclusions: Although no correlation between sST2 levels and myocardial fibrosis was found, sST2 may provide some additional information about hypertrophy extension. NT-proBNP and hs-cTnT are useful biomarkers in assessment of hypertrophy and fibrosis in HCM.