A response adaptive design for ordinal categorical responses. Issue 6 (2nd November 2018)

• Record Type: Journal Article
• Authors: Biswas, Atanu; Bhattacharya, Rahul; Das, Soumyadeep
• Is Part Of: Journal of biopharmaceutical statistics. Volume 28:Issue 6(2018)
• Page Start: 1169
• Page End: 1181
• Publication Date: 2018-11-02
• Subjects: Ordinal categorical responses -- response adaptive design; Pharmacy -- Statistical methods -- Periodicals; Drugs -- Testing -- Statistical methods -- Periodicals; Biometry -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacokinetics -- Periodicals; 615.19
• DOI: 10.1080/10543406.2018.1439053
• Languages: English
• ISSNs: 1054-3406

Abstract

ABSTRACT: A two treatment response adaptive design is developed for phase III clinical trials with ordinal categorical treatment outcome using Goodman-Kruskal measure of association. Properties of the proposed design are studied both empirically and theoretically and the acceptability is further illustrated using two real data-sets; one from a clinical trial with trauma patients and the other from a trial with patients having rheumatoid arthritis.