A two-stage adaptive allocation design for survival outcome with informative censoring. (2nd October 2018)

• Record Type: Journal Article
• Authors: Bhattacharya, Rahul; Shome, Madhumita
• Is Part Of: Journal of statistical theory and practice. Volume 12:Number 4(2018)
• Page Start: 813
• Page End: 836
• Publication Date: 2018-10-02
• Subjects: Clinical trials -- two-stage allocation -- informative censoring; 62L05; 519.505
• DOI: 10.1080/15598608.2018.1479992
• Languages: English
• ISSNs: 1559-8608

Abstract

ABSTRACT: An adaptive two-stage allocation design is developed for survival responses subject to independent informative censoring. The asymptotic p value of a score test related to a hypothesis of treatment effectiveness is used to set the assignment probability of the second stage. Several characteristics of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with those of an existing competitor. Applicability of the proposed design is also illustrated through a real data.