Tumor Protein p53 (TP53) Gene and Left Main Coronary Artery Disease. (September 2018)

• Record Type: Journal Article
• Authors: Kolovou, Vana; Tsipis, Angelos; Mihas, Constantinos; Katsiki, Niki; Vartela, Vasiliki; Koutelou, Maria; Manolopoulou, Dionisia; Leondiadis, Evaggelos; Iakovou, Ioannis; Mavrogieni, Sophie; Kolovou, Genovefa
• Is Part Of: Angiology. Volume 69:Number 8(2018)
• Page Start: 730
• Page End: 735
• Publication Date: 2018-09
• Subjects: tumor protein p53 -- polymorphisms -- coronary artery disease -- left main -- Arg72Pro; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319718760075
• Languages: English
• ISSNs: 0003-3197

Abstract

Patients with left main (LM) coronary artery disease (CAD) are at the highest risk of cardiovascular events. We evaluated possible gene polymorphisms of tumor protein 53 ( TP53, rs1042522, p.Arg72Pro ) that can differentiate LM-CAD from patients with more peripheral CAD (MP-CAD) and healthy participants (control group) in 520 individuals (LM-CAD, n = 175; MP-CAD, n = 185; and control group, n = 160). Patients with LM-CAD had the lowest Arg/Arg genotype frequency (36.0%) compared with the MP-CAD (57.3%) and control groups (61.9%), P < .001 for both comparisons. Similarly, the Arg allele was more frequent in the control group than in patients with MP-CAD (78.8% vs 73.2%; P = .007) and LM-CAD (78.8% vs 64.0%; P < .001). The Arg/Pro genotype was more frequent in the LM-CAD group compared with the MP-CAD and control groups (56.0, 31.9, and 33.8, respectively, P < .001 for both comparisons). Furthermore, the frequency of Arg/Arg genotypes was the lowest in the LM-CAD group compared with the MP-CAD and control groups. Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process. Replication studies are needed to evaluate this association.