Hypopharyngeal cancer: A state of the art review. (November 2018)

• Record Type: Journal Article
• Authors: Garneau, Jonathan C.; Bakst, Richard L.; Miles, Brett A.
• Is Part Of: Oral oncology. Volume 86(2018)
• Page Start: 244
• Page End: 250
• Publication Date: 2018-11
• Subjects: Hypopharyngeal carcinoma -- Hypopharyngeal cancer -- Laryngeal preservation -- Head and neck squamous cell carcinoma; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2018.09.025
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: Hypopharyngeal squamous cell carcinoma has a reported 5-year overall survival rate of approximately 30–35%. Nearly 50% of patients exhibitrecurrence within the first year after diagnosis. Laryngeal preservation strategies are well supported although long term toxicity is significant. Salvage surgery a common occurrence. Future directions will focus on immunotherapy/targeted therapies to improve survival outcomes. Abstract: Cancer of the hypopharynx is relatively rare and accounts for roughly 3% of all head and neck cancers. Unfortunately, hypopharyngeal carcinoma has one of the worst prognosis of all head and neck cancers with a reported 5-year overall survival rate of approximately 30–35%. Toxicity related to therapy, and the need for surgical salvage continue to dominate the landscape in this disease. In this article, we set out to discuss a comprehensive overview of the current management principles, recent literature and evidence based therapeutic options surrounding treatment for hypopharyngeal squamous cell carcinoma, with a special focus on the evolution of an organ sparing paradigm.