Biallelic Parkin (PARK2) mutations can cause a bvFTD phenotype without clinically relevant parkinsonism. (October 2018)

• Record Type: Journal Article
• Authors: Zimmermann, Milan; Wilke, Carlo; Schulte, Claudia; Hoffmann, Jessica; Klopfer, Jasmin; Reimold, Matthias; Brockmann, Kathrin; Synofzik, Matthis
• Is Part Of: Parkinsonism & related disorders. Volume 55(2018)
• Page Start: 145
• Page End: 147
• Publication Date: 2018-10
• Subjects: PARK2 -- Frontotemporal dementia -- Psychiatry -- Parkinsonism -- Neuropsychiatry -- Dementia -- Behavior; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2018.06.006
• Languages: English
• ISSNs: 1353-8020

Abstract

Highlights: The phenotypic spectrum of Parkin mutations is larger than previously assumed. It can include predominant bvFTD phenotypes with only mild parkinsonism, with disease onset above 50 years. Frontotemporal networks are vulnerable to Parkin disease.