Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers. Issue 43 (17th October 2018)

• Record Type: Journal Article
• Authors: Yamazaki, Yuji; Nambu, Yukiko; Ohmae, Masashi; Sugai, Manabu; Kimura, Shunsaku
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 43(2018)
• Page Start: 8095
• Page End: 8105
• Publication Date: 2018-10-17
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01955j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Immune responses against Lewis Y (LY) displayed at varying densities on the nanocarriers were studied. Abstract : Immune responses against Lewis y (LY) displayed on nanocarriers at different surface densities were studied. The high surface density of LY was obtained by the A2 B-type amphiphilic polypeptides having LY at the two terminals [LY-poly(sarcosine)2 - b -(l - ord -Leu-Aib)6 ]. The equimolar mixture of these two amphiphilic polypeptides formed interdigitated planar sheet-like molecular assemblies densely displaying LY (G4). G4 seemed to induce the anti-LY IgM upon immunization to BALB/c mice by only a single administration. However, the amount of anti-LY IgM produced was moderate and significantly less than that induced by two administrations of the other molecular assembly (G1) with the average surface density of LY at a 1/4 of that of G4. Further, the anti-LY IgM produced after two administrations of G4 lowered the avidity more than after one administration.