Cu transfer from amyloid-β4–16 to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(ii)-load states. Issue 89 (24th October 2018)

• Record Type: Journal Article
• Authors: Santoro, Alice; Wezynfeld, Nina Ewa; Stefaniak, Ewelina; Pomorski, Adam; Płonka, Dawid; Krężel, Artur; Bal, Wojciech; Faller, Peter
• Is Part Of: Chemical communications. Volume 54:Issue 89(2018)
• Page Start: 12634
• Page End: 12637
• Publication Date: 2018-10-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc06221h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Copper transfer from Cu(ii )amyloid-β4–16 to human Zn7 -metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA. Abstract : Copper transfer from Cu(ii )amyloid-β4–16 to human Zn7 -metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA. Glutamate facilitates the Cu(ii ) release, and Zn4–6 -metallothionein-3 react more rapidly. These mechanisms are additive, proving the intricate and interconnected network of zinc and copper trafficking between biomolecules.