Ph3P-mediated highly selective C(α)–P coupling of quinone monoacetals with R2P(O)H: convenient and practical synthesis of ortho-phosphinyl phenols. Issue 22 (25th October 2018)

• Record Type: Journal Article
• Authors: Shen, Ruwei; Zhang, Ming; Xiao, Jing; Dong, Chao; Han, Li-Biao
• Is Part Of: Green chemistry. Volume 20:Issue 22(2018)
• Page Start: 5111
• Page End: 5116
• Publication Date: 2018-10-25
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c8gc02918k
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : The Ph3 P-mediated C(α)–P coupling reaction of quinone monoacetals with secondary phosphine oxides is developed to provide an effective method for the synthesis of a wide array of ortho -phosphinyl phenols in good to excellent yields. Abstract : A highly selective Ph3 P-mediated C(α)–P coupling reaction of quinone monoacetals with secondary phosphine oxides is developed to provide an effective method for the synthesis of a wide array of ortho -phosphinylphenols in good to excellent yields. This protocol can be adopted for scale-up synthesis directly from cheap and abundant phenols, and the products can be easily obtained in high yields by simple filtration without the use of organic extraction or chromatography.