Fatal Poisoning with Both Dichlorvos and Phenthoate1, 2. Issue 6 (30th March 2018)

• Record Type: Journal Article
• Authors: Nara, Akina; Yamada, Chiho; Kodama, Takanori; Saka, Kanju; Takagi, Tetsuya
• Is Part Of: Journal of forensic sciences. Volume 63:Issue 6(2018)
• Page Start: 1928
• Page End: 1931
• Publication Date: 2018-03-30
• Subjects: forensic science -- forensic toxicology -- organophosphate -- dichlorvos -- phenthoate -- cholinesterase activity -- carboxylesterase; Medical jurisprudence -- Periodicals; Forensic sciences -- Periodicals; Forensic Medicine -- Periodicals; Gerechtelijke geneeskunde; Gerechtelijke chemie; Gerechtelijke psychiatrie; 363.2505
• DOI: 10.1111/1556-4029.13781
• Languages: English
• ISSNs: 0022-1198

Abstract

Abstract: Organophosphates are widely used as pesticides. However, organophosphates are occasionally orally ingested to commit suicide. In this case, a man in his late 80s committed suicide by ingesting both dichlorvos and phenthoate. Autopsy findings revealed a characteristic volatile odor from his mouth, stomach, lungs, liver, and kidneys. The esophageal mucosa was denatured and had lost elasticity. Serum cholinesterase activity was 9 IU/L. Toxicological analyses performed using high‐performance liquid chromatography–tandem mass spectrometry revealed that dichlorvos concentrations in the left and right cardiac blood samples were 11.6 and 4.6 μg/mL, respectively. Phenthoate concentrations in the left and right cardiac blood samples were 5.8 and 0.51 μg/mL, respectively. The total amounts of dichlorvos and phenthoate in the stomach were 7.35 and 4.55 g, respectively. The case history, autopsy findings, and toxicological analyses indicated that the cause of death was acute fatal poisoning after oral ingestion of both dichlorvos and phenthoate.