Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment. Issue 42 (18th October 2018)

• Record Type: Journal Article
• Authors: Gil, Yeong-Gyu; Kang, Seounghun; Chae, Ari; Kim, Young-Kwan; Min, Dal-Hee; Jang, Hongje
• Is Part Of: Nanoscale. Volume 10:Issue 42(2018)
• Page Start: 19810
• Page End: 19817
• Publication Date: 2018-10-18
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c8nr07172a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Porous palladium nanoparticles were designed and synthesized to maximize the pharmacological activity of the chaga mushroom ( Inonotus obliquus ) extract, which has anticancer and antibacterial activities. Abstract : Porous palladium nanoparticles were designed and synthesized to maximize the pharmacological activity of the chaga mushroom ( Inonotus obliquus ) extract, which has anticancer and antibacterial activities. In the present study, we synthesized anisotropic porous Pd nanostructures with ultraviolet-visible-near infrared whole wavelength region absorption using chaga extract concentration-dependent reductant-mediated synthesis. The porous Pd nanoparticles exhibited a surface chaga extract-derived anticancer effect, controlled delivery of doxorubicin through electrostatic interaction, and a photothermal conversion effect under 808 nm laser irradiation. The combined application of the three cancer treatment approaches clearly demonstrated the feasibility of synergistic tri-modal therapy. The present platform using Pd, which is a key constituent element of nanocatalysts but is not commonly used in biological applications, suggests numerous applications utilizing Pd nanostructures, as well as the potential development of new cancer therapies.