BoneNET: a network model of bone microstructure and dynamics. (1st January 2013)

• Record Type: Journal Article
• Authors: Kim, Taehyong; Bone, Lawrence; Ramanathan, Murali; Zhang, Aidong
• Is Part Of: International journal of data mining and bioinformatics. Volume 8:Number 2(2013)
• Page Start: 123
• Page End: 149
• Publication Date: 2013-01-01
• Subjects: computational model of bone microstructure -- bone strength -- BMD -- bone mineral density -- bone remodelling dynamics -- osteoporosis; Data mining -- Periodicals; Bioinformatics -- Periodicals; 006.312
• Languages: English
• ISSNs: 1748-5673

Abstract

We develop a network model of bone microstructure and dynamics, BoneNET, which is capable of quantitative assessment of Bone Mineral Density (BMD) and bone remodelling dynamics. First, we introduce a network model of bone microstructure by describing structural properties and process of bone network modelling. Secondly, we explain a mathematical model of bone microstructure by analysing the density for mineralised fibres of bone microstructure. Finally, we provide a bone remodelling dynamics among osteoblast and osteoclast and study bone networks by proposing several measurements to calculate bone strength and identify critical elements in bone microstructure.