Thiourea‐Bridged Nanodiamond Glycoconjugates as Inhibitors of Bacterial Adhesion (Eur. J. Org. Chem. 25/2015). Issue 25 (September 2015)

• Record Type: Journal Article
• Authors: Fessele, Claudia; Wachtler, Stefan; Chandrasekaran, Vijayanand; Stiller, Carina; Lindhorst, Thisbe K.; Krueger, Anke
• Is Part Of: European journal of organic chemistry. Issue 25(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-09
• Subjects: Nanoparticles -- Diamond -- Carbohydrates -- Conjugation -- Bioconjugation -- Surface chemistry -- Bacterial adhesion -- Sandwich assay; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201590070
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The cover picture shows glyconanodiamond where the sugars are immobilized onto the diamond by thiourea bridging. This novel ligation technique for the functionalization of nanodiamond enables the grafting of different types of saccharide motifs. These glycoconjugates can be used to probe the carbohydrate‐specific interaction of bacteria and furthermore to inhibit biofilm formation. The article also reports on the quantification of bacterial adhesion to different glyconanodiamond conjugates by employing a tailor‐made sandwich assay. Details are discussed in the article by T. K. Lindhorst, A. Krueger et al. on5519 ff .