A One‐Pot Synthesis of Symmetrical and Unsymmetrical Dipeptide Ureas. Issue 25 (30th July 2015)

• Record Type: Journal Article
• Authors: Fayad, Antoine Abou; Pubill‐Ulldemolins, Cristina; Sharma, Sunil V.; Day, David; Goss, Rebecca J. M.
• Is Part Of: European journal of organic chemistry. Issue 25(2015)
• Page Start: 5603
• Page End: 5609
• Publication Date: 2015-07-30
• Subjects: Peptides -- Dipeptide -- Urea -- Isotopic labelling; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500589
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: We describe a flexible and high yielding synthesis of 1, 3‐disubstituted ureas that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to 13 C‐labelled ureas, from amino acids and carbon dioxide at atmospheric pressure. Abstract : We describe a flexible and high yielding synthesis of 1, 3‐disubstituted ureas, that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to 13 C labelled ureas, from amino acids and carbon dioxide at atmospheric pressure.