Agent-based model of macrophage action on endocrine pancreas. (1st October 2012)

• Record Type: Journal Article
• Authors: Martínez, Ignacio V.; Gómez, Enrique J.; Elena Hernando, M.; Villares, Ricardo; Mellado, Mario
• Is Part Of: International journal of data mining and bioinformatics. Volume 6:Number 4(2012)
• Page Start: 355
• Page End: 368
• Publication Date: 2012-10-01
• Subjects: type 1 diabetes -- endocrine pancreas -- agent-based model -- simulation -- bioinformatics -- autoimmune response -- autoimmunity innate immune system -- beta cell -- macrophage -- phagocytosis; Data mining -- Periodicals; Bioinformatics -- Periodicals; 006.312
• Languages: English
• ISSNs: 1748-5673

Abstract

This paper proposes an agent-based model of the action of macrophages on the beta cells of the endocrine pancreas. The aim of this model is to simulate the processes of beta cell proliferation and apoptosis and also the process of phagocytosis of cell debris by macrophages, all of which are related to the onset of the autoimmune response in type 1 diabetes. We have used data from the scientific literature to design the model. The results show that the model obtains good approximations to real processes and could be used to shed light on some open questions concerning such processes.