Photoinduced DNA Crosslink Formation by Dichloridooxidovanadium(IV) Complexes of Polypyridyl Bases. Issue 24 (30th July 2015)

• Record Type: Journal Article
• Authors: Banerjee, Samya; Dixit, Akanksha; Kumar, Arun; Mukherjee, Sanjoy; Karande, Anjali A.; Chakravarty, Akhil R.
• Is Part Of: European journal of inorganic chemistry. Issue 24(2015)
• Page Start: 3986
• Page End: 3990
• Publication Date: 2015-07-30
• Subjects: Bioinorganic chemistry -- DNA crosslinking -- Vanadium -- Antitumor agents -- Apoptosis; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201500587
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract: Oxidovanadium(IV) complexes [VO(pyphen)Cl2 ] (1 ) and [VO(pydppz)Cl2 ] (2 ), where pyphen is 2‐(2′‐pyridyl)‐1, 10‐phenanthroline and pydppz is 3‐(pyridin‐2‐yl)dipyrido[3, 2‐a:2′, 3′‐ c ]phenazine, show remarkable photoinduced DNA crosslinking ability and photocytotoxicity. The complexes are non‐electrolytes in DMF, 1:1 electrolytes in 20 % aqueous DMF, and 1:2 electrolytes in 20 % aqueous DMF upon photoirradiation with visible light of 400–700 nm. The paramagnetic complexes, which have one unpaired electron, show a d–d band near 780 nm in aqueous DMF. The IR data suggest a V=O moiety trans to a V–N bond. Complex [VO(pydppz)Cl2 ] (2 ), as a novel photoinducible nuclear ds‐DNA crosslinking agent, shows visible‐light‐induced cytotoxicity in HeLa and MCF‐7 cancer cells by an apoptotic pathway, giving IC50 values of 0.87 ± 0.07 and 1.4 ± 0.2 μM, respectively, while being essentially nontoxic (IC50 > 40 μM ) in the dark and less toxic in normal MCF‐10A cells. Abstract : Oxidovanadium(IV) complexes of polypyridyl bases having two dissociable chloride ligands show DNA crosslink formation involving nuclear DNA in a buffer medium upon photoirradiation with visible light of 400–700 nm. The complexes are remarkably photocytotoxic in cancer cells while being essentially nontoxic in the dark.