Precise synchronization of hyperthermia–chemotherapy: photothermally induced on-demand release from injectable hydrogels of gold nanocages. Issue 42 (23rd October 2018)

• Record Type: Journal Article
• Authors: Wan, Jiangshan; Geng, Shinan; Zhao, Hao; Peng, Xiaole; Xu, Jiabao; Wei, Meihe; Mao, Junxiong; Zhou, Yang; Zhu, Quan; Zhao, Yanbing; Yang, Xiangliang
• Is Part Of: Nanoscale. Volume 10:Issue 42(2018)
• Page Start: 20020
• Page End: 20032
• Publication Date: 2018-10-23
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c8nr06851h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Temperature sensitive polymers were modified onto gold nanocages, and the resultant temperature sensitive hydrogels achieved precise synchronization of hyperthermia and chemotherapy by the on-demand release. Abstract : Though a therapeutic sequence plays a key role in tumor therapy, little attention has been paid to its influence on multimodal combined therapy. Herein, we developed gold nanocages (GNC@PNA- hls ) decorated with two kinds of temperature sensitive p( N -isopropyl-acrylamide-acrylic acid) copolymers (PNA- hs and PNA- ls ) for precise antitumor coordination of thermo-chemotherapy. Doxorubicin-loaded GNC@PNA- hls (Dox-GNC@PNA- hls ) showed a steady photothermally induced on-demand release under multiple near-infrared (NIR) irradiations. In vitro evaluations indicated that concurrent thermo-chemotherapy treatments (Dox − L) showed the best antitumor effect, compared with the sequence of either doxorubicin treatment followed by NIR radiation (Dox + L) or NIR radiation followed by doxorubicin treatment (L + Dox). The in vivo antitumor efficacy also indicated that the tumor volume was totally suppressed ( ca. 0.14 cm 3 ) by the treatment of Dox-GNC@PNA- hls with NIR radiation for 14 days. These results indicated that Dox-GNC@PNA- hls could achieve precise synchronization between hyperthermia and chemotherapy, and effectively enhance their antitumor efficacy.