Photothermal and mechanical stimulation of cells via dualfunctional nanohybrids. (25th October 2016)

• Record Type: Journal Article
• Authors: Chechetka, Svetlana A; Doi, Motomichi; Pichon, Benoit P; Bégin-Colin, Sylvie; Miyako, Eijiro
• Is Part Of: Nanotechnology. Volume 27:Number 47(2016)
• Publication Date: 2016-10-25
• Subjects: carbon nanotube -- cell stimulation -- magnetic nanoparticle -- TRPV2; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/0957-4484/27/47/475102
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Stimulating cells by light is an attractive technology to investigate cellular function and deliver innovative cell-based therapy. However, current techniques generally use poorly biopermeable light, which prevents broad applicability. Here, we show that a new type of composite nanomaterial, synthesized from multi-walled carbon nanotubes, magnetic iron nanoparticles, and polyglycerol, enables photothermal and mechanical control of Ca 2+ influx into cells overexpressing transient receptor potential vanilloid type-2. The nanohybrid is simply operated by application of highly biotransparent near-infrared light and a magnetic field. The technology may revolutionize remote control of cellular function.