Mesial temporal lobe and subcortical grey matter volumes differentially predict memory across stages of multiple sclerosis. (April 2018)

• Record Type: Journal Article
• Authors: Sumowski, James F; Leavitt, Victoria M; Rocca, Maria A; Inglese, Matilde; Riccitelli, Gianna; Buyukturkoglu, Korhan; Meani, Alessandro; Filippi, Massimo
• Is Part Of: Multiple sclerosis. Volume 24:Number 5(2018)
• Page Start: 675
• Page End: 678
• Publication Date: 2018-04
• Subjects: Multiple sclerosis -- memory -- speed -- volumetric MRI -- hippocampus -- thalamus; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458517708873
• Languages: English
• ISSNs: 1352-4585

Abstract

Background/Objective: Memory deficits due to multiple sclerosis (MS) have been variably linked to lower subcortical grey matter (SCGM) and mesial temporal lobe (MTL) volumes. We investigated which is the better predictor and whether this changes across disease stages. Methods/Results: Memory was assessed in 315 patients. Magnetic resonance imaging (MRI) measured volumes of total brain, grey matter, white matter, MTL (hippocampus, amygdala) and SCGM (thalamus, caudate). MTL predicted memory in the total sample and in patients with earlier (<10 years) or later (⩾10 years) relapsing disease. SCGM (specifically thalamus) predicted memory in progressive patients. Conclusions: Neuroanatomical correlates of memory deficits differ across disease stages.