Novel frontiers in calcium signaling: A possible target for chemotherapy. (September 2015)

• Record Type: Journal Article
• Authors: Bonora, Massimo; Giorgi, Carlotta; Pinton, Paolo
• Is Part Of: Pharmacological research. Volume 99(2015:Sep.)
• Page Start: 82
• Page End: 85
• Publication Date: 2015-09
• Subjects: p53 -- Intravital imaging -- Cell death and apoptosis -- Cancer -- Calcium signaling; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2015.05.008
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Intracellular calcium (Ca 2+ ) is largely known as a second messenger that is able to drive effects ranging from vesicle formation to muscle contraction, energy production and much more. In spite of its physiological regulation, Ca 2+ is a strategic tool for regulating apoptosis, especially during transmission between the endoplasmic reticulum and the mitochondria. Contact sites between these organelles are well-defined as signaling platforms where oncogenes and oncosuppressors can exert anti/pro-apoptotic activities. Recent advances from in vivo investigations into these regions highlight the role of the master oncosuppressor p53 in regulating Ca 2+ transmission and apoptosis, and we propose that Ca 2+ signals are relevant targets when developing new therapeutic approaches.