L-carnitine ameliorates dyslipidemic and hepatic disorders induced by a high-fat diet via regulating lipid metabolism, self-antioxidant capacity, and inflammatory response. (May 2015)

• Record Type: Journal Article
• Authors: Su, Chang-Chao; Chang, Chaung-Sung; Chou, Chung-Hsi; Wu, Yi-Hsieng Samuel; Yang, Kuo-Tai; Tseng, Jung-Kai; Chang, Yuan-Yen; Chen, Yi-Chen
• Is Part Of: Journal of functional foods. Volume 15(2015)
• Page Start: 497
• Page End: 508
• Publication Date: 2015-05
• Subjects: Antioxidant effect -- High-fat diet -- L-carnitine -- Lipid homeostasis -- Non-alcoholic fatty liver disease -- Serum lipid; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.04.007
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: L-carnitine (CNT) reduces serum lipids and improves cholesterol profile in high-fat-diet (HFD) fed mice. CNT also reduces liver lipid accumulation and inflammatory responses in HFD fed mice. CNT can enhance fatty acid β-oxidation in livers of HFD fed mice. CNT is not a powerful antioxidant ingredient in HFD fed mice. Abstract: The cardiovascular and liver protection of carnitine (CNT) in a high-fat diet was investigated. Male C57BL/6 mice were divided randomly into four groups: 1) CON: Control, 2) HFD: high-fat diet, 3) CNTL: HFD + 500 mg CNT/kg BW, and 4) CNTH: HFD + 1500 mg CNT/kg BW. After a 25-week experimental period, CNT supplementation reduced ( p < 0.05) serum triacylglycerol (TAG), cholesterol (TC) and LDLC/HDLC ratio, and liver TAG contents. CNT supplementation downregulated ( p < 0.05) gene expressions of lipogenesis, but upregulated ( p < 0.05) gene expressions of cholesterol clearance/catabolism and energy expenditure. Serum trolox equivalent antioxidants capacity (TEAC), and liver glutathione (GSH) contents and glutathione-peroxidase (GPx) activity of HFD fed mice were also increased ( p < 0.05) by CNT supplementation. Besides, proinflammation related gene expressions ( Tlr4 and Nfκb ) and proinflammatory cytokine (TNF-α) contents in livers of HFD fed mice were also decreased ( p < 0.05) by CNT supplementation. Furthermore, in comparison with the ameliorative effects of two-dosage CNT treatments on dyslipidemic and hepatic disorders induced by a high-fat diet, low dosage of CNT seems more effective than high dosage of CNT.