In-vitro release of fragrant l-carvone from electrospun poly(ϵ-caprolactone)/wheat cellulose scaffold. (20th November 2015)

• Record Type: Journal Article
• Authors: Ramamoorthy, Manjula; Rajiv, Sheeja
• Is Part Of: Carbohydrate polymers. Volume 133(2015)
• Page Start: 328
• Page End: 336
• Publication Date: 2015-11-20
• Subjects: l-Carvone -- Wheat cellulose -- Blend -- Poly(ϵ-caprolactone) -- Release kinetics -- Korsmeyer–Peppas model; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.07.015
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: l -Carvone loaded PCL/wheat cellulose (WC) nanofibers were prepared by the electrospinning technique which showed good antimicrobial activity. The in-vitro release ofl -carvone from the PCL-WC fibers was found to follow Korsmeyer–Peppas kinetic model which indicated diffusion controlled mechanism of release. Bioactive PCL-WC scaffold is an ideal fragrant scaffold for antimicrobial textile applications. Abstract: The release kinetics ofl -carvone loaded from electrospun poly(ϵ-caprolactone) (PCL) and Wheat cellulose (WC) blend were studied. WC was extracted from wheat straw, a cost effective agricultural waste by the acid hydrolysis method. A homogeneous solution of PCL-WC (13:3 wt%) was optimized to produce beadless electrospun PCL-WC blend nanofibers. Further, WC and the prepared electrospun PCL-WC blend fibers were systematically characterized by ATR-FTIR, SEM, XRD, TGA, DTGA, and DSC measurements. The hydrophilic character of the blend fibers was analysed using swelling tests and contact angle measurements. The loading efficiency ofl -carvone into the electrospun PCL-WC blend fibers was evaluated to be ∼70%. The in-vitro release ofl -carvone from PCL-WC blend fibers followed Korsmeyer–Peppas kinetic model indicating the diffusion mechanism and the maximum release ofl -carvone was found to be ∼84% over a period of 30 h. These results would offer the prepared PCL-WC blend as an ideal fibrous mesh for fragrant antimicrobial textile applications.