Antimicrosporidian activity of sulphated polysaccharides from algae and their potential to control honeybee nosemosis. (20th November 2015)

• Record Type: Journal Article
• Authors: Roussel, M.; Villay, A.; Delbac, F.; Michaud, P.; Laroche, C.; Roriz, D.; El Alaoui, H.; Diogon, M.
• Is Part Of: Carbohydrate polymers. Volume 133(2015)
• Page Start: 213
• Page End: 220
• Publication Date: 2015-11-20
• Subjects: Apis mellifera -- Honeybee -- Nosema ceranae -- Polysaccharides -- Antimicrosporidian activity -- Algae; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.07.022
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Nosemosis is one of the most common and widespread diseases of adult honeybees. The causative agents, Nosema apis and Nosema ceranae, belong to microsporidia some obligate intracellular eukaryotic parasites. In this study, 10 sulphated polysaccharides from algae were evaluated for their antimicrosporidian activity. They were first shown to inhibit the in vitro growth of the mammal microsporidian model, Encephalitozoon cuniculi . The most efficient polysaccharides were then tested for their ability to inhibit the growth of Nosema ceranae in experimentally-infected adult honeybees. Two polysaccharides extracted from Porphyridium spp. did not show any toxicity in honeybees and one of them allowed a decrease of both parasite load and mortality rate due to N. ceranae infection. A decrease in parasite abundance but not in mortality rate was also observed with an iota carrageenan. Our results are promising and suggest that algal sulphated polysaccharides could be used to prevent and/or control bee nosemosis.