Novel multifunctional colloidal carbohydrate nanofiber electrolytes with excellent conductivity and responses to bone cancer cells. (20th November 2015)

• Record Type: Journal Article
• Authors: Gökmen, Fatma Özge; Rzayev, Zakir M.O.; Salimi, Kouroush; Bunyatova, Ulviya; Acar, Selim; Salamov, Bahtiyar; Türk, Mustafa
• Is Part Of: Carbohydrate polymers. Volume 133(2015)
• Page Start: 624
• Page End: 636
• Publication Date: 2015-11-20
• Subjects: AA acrylic acid -- AM acrylamide -- AMPS 2-acrylamido-2-methyl-1-propanesulfonic acid -- CaCO3 calcium carbonate -- CH/ALG chitosan/alginate -- CMC carboxymethyl cellulose -- CNTs carbon nanotubes -- DMEM dulbecco modified medium -- DS degree of substitution -- FA folic acid -- FCS fetal calf serum -- FESEM field emission scanning electron microscope -- FTIR Fourier transform infrared -- HPM chydroxypropyl methyl cellulose -- Li–CMC lithium–carboxymethyl cellulose -- MBA N, N′-methylenebisacrylamide -- MgCO3 magnesium carbonate -- MRI magnetic resonance imaging -- Na–CMC sodium–carboxymethyl cellulose -- Na–MMT sodium–montmorillonite -- NFCs nanofiber composites -- NH4Br ammonium bromide -- NH4F ammonium fluoride -- ODA–MMT octadecylamine–montmorillonite -- PBS phosphate buffer solution -- PVA polyvinyl alcohol -- SP substitution pattern -- XRD X-ray diffraction; PVA -- Na-CMC -- Organoclay -- Nanocomposites -- Nanofibers -- Electrospinning -- Structure–property relationships -- Morphology -- Conductivity -- Bone cancer cells; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.06.106
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: The multifunctional carbohydrate NFCs were fabricated by green reactive electrospinning. The incorporation of FA (0.5%) essentialy improved morphology and conductivity of NFCs. The effects of temperature, pressure and conduct time on electrical properties were evaluated. The cytotoxic/apoptotic/necrotic analyses were confirmed anticancer activity of FA-NFCs. Reported conductivity and anticancer activity of novel carbohydrate NFCs for the first time. Abstract: This work presents a new approach to fabricating novel polymer nanofiber composites (NFCs) from water solution blends of PVA (hydrolyzed 89%)/ODA–MMT and Na–CMC/ODA–MMT nanocomposites as well as their folic acid (FA) incorporated modifications (NC-3-FA and NC-4-FA) through green electrospinning nanotechnology. The chemical and physical structures and surface morphology of the nanofiber composites were confirmed. Significant improvements in nanofiber morphology and size distribution of the NFC-3-FA and NFC-4-FA nanofibers with lower average means 110 and 113 nm compared with those of NFC-1/NFC-2 nanofibers (270 and 323 nm) were observed. The structural elements of polymer NFCs, particularly loaded partner NC-2, plays an important role in chemical and physical interfacial interactions, phase separation processing and enables the formation of nanofibers with unique morphology and excellent conductivity (NFC-3-FA 3.25 × 10 −9 S/cm and NFC-4-FA 8.33 × 10 −4 S/cm). This is attributed to the higher surface contact areas and multifunctional self-assembled supramacromolecular nanostructures of amorphous colloidal electrolytes. The anticancer activity of FA-containing nanofibers against osteocarcinoma cells were evaluated by cytotoxicity, apoptotic and necrotic analysis methods.