Bifunctionalized dextrans for surface PEGylation via multivalent host–guest interactions. (20th November 2015)

• Record Type: Journal Article
• Authors: Antoniuk, Iurii; Wintgens, Véronique; Volet, Gisèle; Nielsen, Thorbjørn T.; Amiel, Catherine
• Is Part Of: Carbohydrate polymers. Volume 133(2015)
• Page Start: 473
• Page End: 481
• Publication Date: 2015-11-20
• Subjects: Modified dextrans -- Cyclodextrin polymers -- Supramolecular association -- Surface films -- PEGylation; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.07.027
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Dextrans bearing 5000 g/mol PEG chains and adamantyl groups were prepared by copper(I) catalyzed azide-alkyne cycloaddition. The polymers show high affinity to native βCD and βCD-polymers. Bifunctional dextrans form layers on top of βCD-polymers pre-adsorbed on gold. The deposited layers interact mainly via multivalent host–guest interactions. Stability and thickness of the layers can be tuned by varying the degrees of substitution of PEG and adamantyl groups. Abstract: The main goal of this work was to develop a supramolecular chemistry strategy to decorate interfaces with polyethylene glycol (PEG) grafts. A series of novel bifunctionalized dextrans, bearing 40–60 PEG pending chains and 12–24 hydrophobic adamantyl groups, have been prepared by copper(I)-catalyzed azide-alkyne cycloaddition. Their binding properties toward native βCD and βCD polymers were characterized both in solution and at interface using isothermal titration microcalorimetry and surface plasmon resonance. The polymers were found to form stable layers onto neutral and positively charged βCD-polymer films pre-adsorbed on gold surfaces, due to multivalent interpolymer host–guest interactions. The thickness and stability of the layers could be tuned by varying the ratio between the degrees of substitution by PEG and adamantyl groups.