Risk of damage and mortality in SLE patients fulfilling the ACR or only the SLICC classification criteria. A 10-year, inception cohort study. (April 2018)

• Record Type: Journal Article
• Authors: Inês, L; Rodrigues, M; Jesus, D; Fonseca, F P; Silva, J A P
• Is Part Of: Lupus. Volume 27:Number 4(2018)
• Page Start: 556
• Page End: 563
• Publication Date: 2018-04
• Subjects: Systemic lupus erythematosus -- classification criteria -- damage -- mortality -- inception cohort -- prognosis; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203317731534
• Languages: English
• ISSNs: 0961-2033

Abstract

Objective: To compare damage and mortality, from inception up to 10-year follow-up, between SLE patients meeting at baseline the 1997 ACR criteria or only the 2012 SLICC classification criteria. Methods: Patients fulfilling the ACR and/or the SLICC classification criteria for SLE were enrolled at inception and followed-up to 10 years at an academic lupus clinic. Damage was defined as SLICC Damage Index (SDI) score ≥1. We assessed with multivariate Cox models the damage and mortality outcomes, according to SLE classification status at inception, adjusting for potential baseline confounders. Results: We recruited 192 patients (69.8% fulfilling at inception the ACR criteria and 30.2% only the SLICC criteria). During follow-up, 24.0% of patients accrued organ damage and 4.2% died. Patients meeting ACR criteria compared to those with SLICC criteria alone presented during follow-up with more cases of lupus nephritis (35.1% versus 13.8%, p < 0.01), but less thrombotic antiphospholipid syndrome (4.5% versus 17.2%, p < 0.01). The Cox models showed no significant differences in risk for damage [hazard ratio (HR) (95% CI) 0.991 (0.453–2.167)] or death [hazard ratio (HR) (95% CI) 0.694 (0.107–4.506)] between groups. Conclusion: The SLE classification status at inception identified different patterns of clinical phenotype, but did not influence damage accrual or mortality up to 10-year follow-up.