A facile synthesis of norathyriol. (1st January 2013)

• Record Type: Journal Article
• Authors: Qin, Qi-xue; Yang, Jian; Yang, Bo; Liu, Man; Xiao, Dan; Yang, Xuemin
• Is Part Of: Journal of chemical research. Volume 37:Number 1(2013)
• Page Start: 38
• Page End: 39
• Publication Date: 2013-01-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751912X13547158602399
• Languages: English
• ISSNs: 1747-5198

Abstract

In this paper, norathyriol has been synthesised from 2-bromo-4, 5-dimethoxybenzoic acid and 1, 3, 5-trimethoxybenzene by a three-step sequence of transformations involving a Friedel–Crafts acylation with cyclisation and demethylation. The procedure was facile and should be easily scaled-up. The overall yields reached approximately 70%.