Improved synthesis of YT-14, a potent antibiotic to multidrug-resistant strains. (1st July 2018)

• Record Type: Journal Article
• Authors: Wei, Jianhai; Kong, Deyu; Wang, Lei; Zhang, Yinyong; Hu, Wenhao; Yang, Yushe
• Is Part Of: Journal of chemical research. Volume 42:Number 7(2018)
• Page Start: 354
• Page End: 360
• Publication Date: 2018-07-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751918X15314830456124
• Languages: English
• ISSNs: 1747-5198

Abstract

A new practical synthetic approach produced clinical drug candidate YT-14, improving the overall yield from 1.3% to 13.8%. Compared with the previous route, the new route is two steps shorter and all of the steps involve purifications without column chromatography. The advantages of this procedure include simple operating conditions and higher yields.