Cerium(IV) tetrabutylammonium nitrate (CTAN): A mild and efficient N-dearylation agent for synthesis of N-unsubstituted 2-azetidinones. (1st April 2017)

• Record Type: Journal Article
• Authors: Zarei, Maaroof
• Is Part Of: Journal of chemical research. Volume 41:Number 4(2017)
• Page Start: 246
• Page End: 249
• Publication Date: 2017-04-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X14902201357392
• Languages: English
• ISSNs: 1747-5198

Abstract

A simple and efficient protocol for the conversion of N-p-methoxyphenyl, N-p-ethoxyphenyl, N-p-methoxynaphthyl, N-3, 4-dimethoxybenzyl and N-p-methoxybenzyl-2-azetidinones to N-unsubstituted 2-azetidinones using cerium(IV) tetrabutylammonium nitrate (CTAN) in dichloromethane is described. The method is compatible with a number of functional groups, and N-unsubstituted 2-azetidinones can be prepared under mild conditions at room temperature. The reaction is rapid, and pure products are obtained in good yields.